Sevgi Tatar U
نویسنده
چکیده
A sensitive high performance liquid chromatography (HPLC) method for the determination of Norfloxacin in pharmaceutical preparation is described. The proposed method was based on the derivatization of Norfloxacin with 4-chloro-7-nitrobenzofurazan in borate buffer at pH 9.0 to yield a fluorescent product. The chromatographic separation was achieved on a C18 column (150 mm×4.6 mm) using a mobile phase of methanol–water (75:25, v/v) solvent system at 1.1 mL/min flow-rate. The assay was linear over the concentration range of 10 to 500 ng/mL.
منابع مشابه
ScienceDirect - Journal of Chromatography B, Volume 834, Issues 1-2, Pages 1-228 (13 April 2006)
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